Leica FL400

Manufacturer:Leica Microsystems, Germany


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The Leica FL400* in combination with the active substance 5-ALA helps to see the tumor more clearly for a more complete resection of malignant glioma, while sparing healthy brain tissue.

Before surgery, the patient drinks the 5-ALA solution. The aminolevulinic acid is absorbed by the cells in the body, whereas the glioma cells take up more and convert 5-ALA into the fluorescent PPIX. When illuminated under blue light the PPIX in the tumor glows an intense red, while the normal tissue appears blue.

Your Advantages

Visible tumor margins

Under Leica FL400 blue light mode the surgeon and the assistant can observe the vital tumor and the anatomy in high-contrast, bright, and in the full field of view. This means resection is easier to do as fewer changes to the white light mode are necessary.

Quick and easy handling

Changing observation modes is easy. To switch from white light view to blue light fluorescence mode and back requires only the click of a button on the hand or the foot switch. This ensures quick handling and supports the surgical workflow at all times.

Videos in high-definition

Leica Microsystems supports the surgeon with HD technology in all fluorescence configurations and modes - both in white and blue light mode of the Leica FL400. The result: high-quality images on the monitor display and in the records.

Modular design

The fluorescence modules Leica FL400 and FL800 can be combined on the surgical microscopes M720 OH5 and M525 OH4 with standard and HD video cameras. This gives the surgeon the full benefit of all features in all configurations.

IntenseBlue - Leica M720 FL400

The compact design of the Leica M720 microscope combined with the FL400 module enables the surgeon to work in comfort in 5-ALA - and all other applications. Additionally, the system now requires only the intense 400 Watt built-in xenon light source to deliver a bright and clear fluorescence view.

DoubleBlue - Leica M525 FL400

The Leica M525 microscope combined with the FL400 module uses two light sources to create the best excitation, resulting in a bright fluorescence view. The 300 Watt xenon lamp is part of the microscope illumination, while the Karl Storz light source is dedicated to blue light fluorescence only.

Tumor resection

  • (Left) The fluorescence image shows a clear delineation between the tumor and the surrounding tissue. (5-ALA emission in blue light mode)
  • (Right) The non-fluorescence image illustrates how it is considerably more difficult to determine tumor from healthy brain tissue. (Tumor in white light mode)

Surgery with 5-ALA

  • (Left) Under blue light, the surgeon can clearly identify and safely remove the tumor cells labelled with 5-ALA during surgery.
  • (Right) Under normal white light, the tumor perimeters and any remaining tumor residue are hard to spot after resection of necrotic tissue and the solid tumor.

Components controlled by the Leica FL400 module

The image shows all components as they would appear in the 5-ALA fluorescence surgical microscopes Leica M720 OH5 and Leica M525 OH4:

  • blue & white light switching video
  • observation filter in/out
  • second, external light source white & blue mode (only with Leica OH4)
  • video switchboard illumination filter unit
  • illumination module
  • protective glass
  • mode controlled standard or HD camera